Laboratory Response Network for Chemical Threats (LRN-C)

What to know

The Laboratory Response Network for Chemical Threats (LRN-C) is a national network that responds to chemical terrorism and other public health emergencies.

Balls with connecting rods representing a chemical compound.

Overview

The Laboratory Response Network for Chemical Threats (LRN-C) is a national network of Centers for Disease Control and Prevention (ÐÇ¿ÕÓéÀÖ¹ÙÍø) and local and state public health laboratories that responds to chemical terrorism and other public health emergencies. During large-scale national events, state and local LRN-C laboratories assist ÐÇ¿ÕÓéÀÖ¹ÙÍø in testing samples for chemical exposures and serve as front-line conduit for communication among ÐÇ¿ÕÓéÀÖ¹ÙÍø and local health officials, hospitals, and poison control centers. They also provide crucial local and state infrastructure that supports other important state and local public health programs.

Mission‎

Ensure a local and national asset for laboratory response to a wide range of chemical emergencies and emerging threats.

The ÐÇ¿ÕÓéÀÖ¹ÙÍø surge capacity model

  • Level 1 laboratories provide 24/7 assistance to ÐÇ¿ÕÓéÀÖ¹ÙÍø by testing samples in the event of a large-scale chemical emergency. These laboratories must maintain adequate staffing and equipment to support high volume testing with quick turnaround times. ÐÇ¿ÕÓéÀÖ¹ÙÍø also requires these laboratories maintain testing capabilities for exposures to the following high-threat chemical agents: mustard agents, nerve agents, and toxic industrial chemicals. In addition, Level 1 laboratories maintain all Level 2 testing capabilities.
  • Level 2 laboratories must maintain testing capabilities for exposures to chemical terrorism agents such as cyanide, toxic metals, and toxic industrial chemicals. Although Level 2 laboratories test a smaller list of chemical threat agents, LRN-C methods are customizable and can be readily adapted to detect broad classifications of new and emerging threat agents.
  • Level 3 laboratories ensure local support with sample logistics as well as training and outreach with local hospitals. All LRN-C laboratories maintain Level 3 capabilities.

Early detection and accurate identification of chemical threat agents are critical for effective treatment and minimizing additional exposures. ÐÇ¿ÕÓéÀÖ¹ÙÍø ensures the testing capabilities of LRN-C laboratories through the services it provides to the network. ÐÇ¿ÕÓéÀÖ¹ÙÍø program services to LRN-C include:

  • Hands-on laboratory methods training.
  • Response materials for sample testing.
  • Proficiency Testing.
  • Response readiness drills.
U.S. map with state boundaries. Level 1 states are yellow, level 2 states are dark green, level 3 states are light green.
Laboratory Response Network for Chemical Threats

By the numbers

  • 54 LRN-C member laboratories located in the U.S., including one U.S. territory.
  • 44 laboratories can identify exposures to toxic chemical agents such as cyanide, nerve agents, and toxic metals.
  • 10 laboratories with high-threat testing capabilities for mustard agents, nerve agents, and toxic industrial chemical exposures.
  • 8,500 clinical samples can be processed, tested, and reported to ÐÇ¿ÕÓéÀÖ¹ÙÍø within a 24-hour period.
  • 84% of Americans live within 100 miles of an LRN-C laboratory.

LRN-C: A network with many partners

  • Founding partners: ÐÇ¿ÕÓéÀÖ¹ÙÍø, Federal Bureau of Investigation, and the Association of Public Health Laboratories.
  • U.S. Department of Defense.
  • Organization for the Prohibition of Chemical Weapons (OPCW).
  • U.S Food and Drug Administration.
  • U.S Department of Homeland Security.
  • U.S Department of State.
  • Private commercial laboratories.
  • Materials manufacturing vendors.
  • Integrated Consortium of Laboratory Networks (ICLN).
  • HHS Office of the Assistant Secretary for Preparedness and Response (Biomedical Advanced Research and Development Authority).

Download the LRN-C general factsheet PDF