About Young Children with a Contraindication to Pertussis-Containing Vaccines

Key points

  • 星空娱乐官网 recommends a series of diphtheria, tetanus, and pertussis vaccine (DTaP) for children aged younger than 7 years.
  • Use tetanus and diphtheria vaccine (Td) off-label for children aged <7 years who develop a contraindication to pertussis-containing vaccine.
  • If Td is used, follow the same schedule that would be used for DTaP.
  • Children who receive Td in place of DTaP may have sub-optimal protection against diphtheria.
Child sitting on his mother's lap at the doctor with a bandaid on his arm from receiving a vaccination.

Background

星空娱乐官网 recommends a series of DTaP for children aged <7 years. For children aged <7 years who develop a contraindication to pertussis-containing vaccines, 星空娱乐官网 previously recommended DT instead of DTaP.

Vaccine availability

Sanofi Pasteur, historically the sole licensed DT manufacturer in the United States, discontinued the vaccine in late 2022. Currently, there’s no licensed DT available in the United States. The current Td supply is adequate. The anticipated increase in Td use is relatively small, considering the rarity of developing a contraindication to pertussis-containing vaccine.

Helpful vaccine abbreviations

DT= diphtheria toxoid- and tetanus toxoid-containing vaccine

DTaP = diphtheria toxoid-, tetanus toxoid-, and acellular pertussis-containing vaccine

Td = tetanus toxoid- and diphtheria toxoid-containing vaccine

What the data show

Rarity of contraindications

There's only one contraindication specific to the pertussis component in DTaP: encephalopathy. Encephalopathy, within 7 days of vaccination, is a contraindication when it's not attributable to another identifiable cause.

Experts don't know the exact number of people who experience this adverse reaction, but data suggest it's extremely rare.

A family history of a contraindication or reaction to pertussis-containing vaccines isn't a contraindication for young children to receive DTaP.

Uncertain impact on diphtheria protection

Td contains a lower dose (approximately 1/12th the amount) of diphtheria toxoid compared to DT. The impact of this lower dose on the protection provided against diphtheria in young children is uncertain. Available evidence suggests young children who receive Td in place of DTaP may have sub-optimal protection against diphtheria1234567.

In the primary series for young children

No available data evaluate Td effectiveness against diphtheria when used as part of a primary series in young children.

As the booster dose for young children

Several studies have looked at low-dose, diphtheria toxoid-containing vaccines used for a booster dose in children aged <7 years. Available data demonstrated mixed findings regarding the level of protective diphtheria antibody generated234.

In the primary series for older children and adults

Limited data are available on the use of Td for primary vaccination of older children and adults. Available data suggest that low-dose diphtheria toxoid-containing vaccines may not reliably generate a protective diphtheria response567.

Guidance

First dose

星空娱乐官网 recommends young children receive DTaP as the first dose in the diphtheria, tetanus, and pertussis childhood vaccination series. 星空娱乐官网 recommends this dose at 2 months of age.

Keep Reading: Pertussis Vaccination Recommendations

Subsequent doses

星空娱乐官网 recommends continued use of DTaP unless a contraindication to pertussis-containing vaccines develops. For young children with a contraindication to pertussis-containing vaccines, vaccine providers may administer Td for all recommended remaining DTaP doses.

Parent counseling

Counsel concerned parents about:

  1. What is and isn't a contraindication to pertussis-containing vaccines
  2. How rare contraindications are to pertussis-containing vaccines
  3. How their child may have less protection against diphtheria and no additional protection against pertussis if they receive Td instead of DTaP

Resources

Contraindications and precautions

General Best Practice Guidelines for Immunization

Pink Book chapter on pertussis

Immunization schedules

Child and adolescent immunization schedule

Print
Content Source:
National Center for Immunization and Respiratory Diseases; Division of Bacterial Diseases
  1. Kahn F, Lepp T, Storsaeter J. . Acta Paediatrica. 2023; 112(2):242-245.
  2. Ciofi degli Atti ML, Salmaso S, Cotter B, et al. . Vaccine. 2001;20(1–2):74–9.
  3. Meyer CU, Habermehl P, Knuf M, et al. . Hum Vaccin. 2008;4(3):203–9.
  4. Stojanov S, Liese JG, Bendjenana H, et al. . Pediatr Infect Dis J. 2000;19(6):516–21.
  5. Myers MG, Beckman CW, Vosdingh RA, Hankins WA. . JAMA. 1982;248(19):2478–80.
  6. Larsen K, Ullberg-Olsson K, Ekwall E, Hederstedt B. . J Biol Stand. 1987;15(2):109–16.
  7. Sutter RW, Hardy R, Kozlova A, et al. . J Infect Dis. 2000;181(Supplement 1):S197–S202.